1.
Southeast Asian J Trop Med Public Health
;
1998 Sep; 29(3): 563-6
Article
in English
| IMSEAR
| ID: sea-33562
ABSTRACT
Immunogenicity of Trichinella britovi (Japanese isolate, cord ISS 408) muscle larvae irradiated with 5 mJ/cm2 of short wavelength ultraviolet (UV) was studied using homologous challenge infections. SCID mice vaccinated with UV-attenuated larvae showed no resistance, although its congenic CB-17 mice exhibited remarkable immunity. Following challenge vaccinated Mongolian gerbils, Meriones unguiculatus, did not show significant immunity. Use of these animal models vaccinated with UV-attenuated larvae will contribute to the investigation of immune mechanisms against Trichinella infection and also to the development of a vaccine of trichinellosis.